Testosterone Undecanoate is commonly known by its trade name Andriol. Andriol has both anabolic and androgenic effects on the body. It is the only testosterone that is available in both oral and injectable formulations. As a depot intramuscular preparation, it has a longer elimination half life, allowing for longer dosing intervals.
An Andriol steroid research in Asia showed that there is a possible indication of this steroid as a male contraceptive. Once Andriol is in the blood stream, it provides the pituitary with a negative feedback so as to reduce the production of follicle stimulating and luteinizing hormones. This leads to cut off of the signal to the testes to produce endogenous testosterone. Reduced endogenous testosterone leads to low sperm production. Following Andriol use, there is reduction of the ejaculatory volume and quantity of sperm. This reverses once steroid use is stopped hence why the consideration to use it as a contraceptive.
In transgender men, Andriol has been used as part of the hormone replacement therapy. It provides the exogenous anabolic steroid that they do not produce. Consistent use leads to development of the secondary sexual characteristics seen in men. They include deepening of the voice, growth of a beard, increased sexual drive and aggression. It is also used for hormonal replacement in older men or men with hypogonadism. This leads to muscle strength and bulk and increased energy levels and bone strength.
Research has also shown that the use of Andriol is associated with increased levels of low density lipoprotein. This cholesterol type is responsible for the cardiovascular side effects of most anabolic steroids. There is an increased risk for development of coronary artery disease, hypertension and sudden cardiac events.
Using dosages that are higher than usually recommended has been shown to cause some unpleasant effects. Stopping the use allows the body to return to normal physiology.